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SolicitationClosed

Protein ENGineering (PENG)

DEPT OF DEFENSE · DEF ADVANCED RESEARCH PROJECTS AGCY

Official notice ↗
Plain text

This notice is no longer open for responses. Find active opportunities

Contract Details

Solicitation number
DARPA-PS-26-129
Notice ID
DARPA-PS-26-129
Opportunity Type
Solicitation
Agency
DEPT OF DEFENSE
Sub-Agency
DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office
DEF ADVANCED RESEARCH PROJECTS AGCY
Posted Date
Friday, August 21, 2026
Response Deadline
Oct 19, 2026
NAICS Code
541714 - Research and Development in Biotechnology (except Nanobiotechnology)
PSC Code
AC12
Set-Aside
Full & Open Competition
Status
Closed
View on SAM.gov

Description

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.

Documents and contact

Check the official notice for attachments and access requirements ↗

Contact
BAA Coordinator
Email
PENG@darpa.mil

Observed opportunity history

This is the history collected by Gov Contract Finder. Times show when information was captured or a version was assembled, not when SAM.gov originally changed it. Earlier revisions may be missing.

Publications are grouped by matching evidence; revision relationships are inferred.

The original SAM.gov root publication has not been verified.

History

  1. Opportunity version

    Initial information

    Protein ENGineering (PENG)

    Solicitation: DARPA-PS-26-129

    Publication: 8d7bb66b691a4def9e7efe4d4345bb7a

    Current publication

    Changed fields: AAC Code, Active, AdditionalInfoLink, ArchiveDate, ArchiveType, Award$, AwardAmount, AwardDate, AwardNumber, Awardee, BaseType, CGAC, City, ClassificationCode, CountryCode, Department/Ind.Agency, Description, FPDS Code, Industry, Link, NaicsCode, NoticeId, Office, OrganizationType, PopCity, PopCountry, PopState, PopStreetAddress, PopStreetAddress2, PopZip, PostedDate, PrimaryContact, ResponseDeadLine, SecondaryContact, SetASide, SetASideCode, Sol#, State, Sub-Tier, Title, Type, ZipCode, awardeeCageCode, awardeeUei, descriptionUrl, fullParentPathCode, fullParentPathName, groupingConfidence, logicalOpportunityId, naicsCodes, pointOfContact, resourceLinks, samNoticeId, samRootId, solicitationNumber, source, sourceResourceCount, sourceResourceIds

    First established information: Department/Ind.Agency, Description, Office, Sub-Tier

  2. Opportunity capture

    Initial information

    Protein ENGineering (PENG)

    Solicitation: DARPA-PS-26-129

    Publication: 8d7bb66b691a4def9e7efe4d4345bb7a

    Current publication

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