Requirements: 1. Purpose Dovetail Genomics LLC Micro-C service employs micrococcal nuclease (MNase) digestion to generate highly uniform fragments, enabling precise capture of nucleosome positioning with even genomic coverage. This approach provides increased mapping resolution at the nucleosome level, while proximity ligation data enriched for long-range informative reads allows detection of higher-order chromatin organization, including chromatin loops and interaction frequencies. The purpose of this Statement of Work is to acquire Dovetail Genomics LLC Micro-C services for samples processing and associated data generation in support of NCI/CCR/LRBGE research on the effects of substrate stiffness on 3D chromatin architecture in colon cancer cell lines. This information will allow us to b
HEALTH AND HUMAN SERVICES, DEPARTMENT OF is actively seeking qualified contractors for research and development in the physical, engineering, and life sciences (except nanotechnology and biotechnology) with a set-aside for Small Business businesses in BETHESDA, MD. This set-aside designation means eligible businesses face reduced competition from larger firms.
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