IDENTIFY Study Participants 5-Base Sample Preparation and Whole Genome Multiomic Profiling

The Prenatal Genomics and Therapy Section (PGTS), Center for Precision Health Research (CPHR), National Human Genome Research Institute (NHGRI), requires 5-base whole genome sequencing services for stored plasma-derived cell-free DNA samples collected under the IDENTIFY study. These samples were obtained from women who received prenatal cell-free DNA sequencing results suggestive of maternal malignancy. 5Base sample prep and whole genome multiomic profiling at 30x is required to generate high-resolution genomic and epigenomic data suitable for tissue-of-origin analyses. The objective of this acquisition is to obtain high-quality, comprehensive 5-base sequencing data that will support the development and refinement of computational models to determine the tissue source of incidentally detec