Nanobody against NPR-C for growth disorder
Key Takeaways
- Set-aside for Small Business businesses
- Work to be performed in BETHESDA, MD
- Industry: Research and Development in Biotechnology (except Nanobiotechnology)
Contract Details
- Notice ID
- 75N98026Q01031
- Opportunity Type
- Combined Synopsis/Solicitation
- Sub-Agency
- NATIONAL INSTITUTES OF HEALTH
- Office
- NATIONAL INSTITUTES OF HEALTH OLAO
- Posted Date
- Tuesday, August 18, 2026
- Response Deadline
- Friday, August 28, 2026
- PSC Code
- R499
- Set-Aside
- Small Business Set Aside - Total
- Place of Performance
- BETHESDA, MD, 20892
- Status
- Active
Description
See attached Word document. Project Title: Nanobody against NPR-C for growth disorder 1. Project Overview 1.1 Background We sought to develop nanobodies (VHH) against human NPR-C with high affinity and specificity for future clinical use. These nanobodies could potentially be further developed into therapeutics for treatment of growth disorders such as achondroplasia. 1.2 Main Objectives - generation of antigens needed for immunization - immunization of Alpaca/Ilama with target antigens generated - generation of immunized phage/yeast library and in vitro screening using the library - alternatively, single B-cell screening and sequencing instead of phage/yeast library generation/screening. - downstream functional confirmation of VHH nanobodies binding to target antigens - generation of fina
Why This Opportunity Matters
HEALTH AND HUMAN SERVICES, DEPARTMENT OF is actively seeking qualified contractors for research and development in biotechnology (except nanobiotechnology) with a set-aside for Small Business businesses in BETHESDA, MD. This set-aside designation means eligible businesses face reduced competition from larger firms.
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