GUARDIAN

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative approaches to controllably eliminate invasive species from defined areas, primarily focused on New World Screwworm (NWS) and Brown Tree Snake (BTS)(Guam), using genetic drive technologies (GDT). GUARDIAN is composed of three optionsTechnical Areas (TAs). The first Option TA is focused on BTS eradication. Performerroposers are expected to complete modeling and laboratory testing of genetic elements in the 18-month Phase 1 and contained (laboratory or greenhouse) testing during the 18-month Phase 2. Option TA1 will emphasize: genetic precision to ensure off-target effects and GDT resistance is minimized; GDT control by designing counter measures/GDT immunization to add additional safeguards; and fieldability by en